Guipi Pills, a Chinese patent medicine. It is composed of Codonopsis pilosula, stir-fried Atractylodes macrocephala, roasted Astragalus membranaceus, roasted Licorice root, Poria cocos, processed Polygala tenuifolia, stir-fried Ziziphus jujuba seeds, longan pulp, Angelica sinensis, Aucklandia lappa, and jujube (pitted). It has the effects of invigorating Qi and strengthening the spleen, nourishing blood and calming the mind. It is used for deficiency of both heart and spleen, shortness of breath and palpitations, insomnia and dreaminess, dizziness, limb fatigue, and loss of appetite.
Element
Codonopsis pilosula, stir-fried Atractylodes macrocephala, roasted Astragalus membranaceus, roasted Licorice root, Poria cocos, processed Polygala tenuifolia, stir-fried Ziziphus jujuba seeds, longan pulp, Chinese angelica, costusroot, jujube (pitted).
Characteristics
This product is brown-colored water-honey pill, small honey pill or large honey pill; it has a faint odor and tastes sweet and then slightly bitter and spicy.
Main Benefits
Invigorate Qi and strengthen the spleen, nourish blood and calm the mind.
Indications
This product is used for deficiency of both heart and spleen, shortness of breath, palpitations, insomnia, dizziness, limb fatigue, and loss of appetite.
Clinical Application and Guidelines
1. Li Si conducted a study on the therapeutic effect of desogestrel ethinyl estradiol tablets plus mifepristone and Guipi pills on functional uterine bleeding during menopause transition period and concluded that desogestrel ethinyl estradiol tablets plus mifepristone and Guipi pills can achieve safe and definite therapeutic effects in the treatment of patients with functional uterine bleeding during menopause transition period, and the bleeding can be controlled more quickly, which is worthy of wide clinical application. (World Latest Medical Information Abstracts, 2018, 18 (48): 125+127).
2. Wang Xiaowen conducted a clinical observation study on the treatment of MHD gastroesophageal reflux with Guipi Pills combined with omeprazole and concluded that Guipi Pills combined with omeprazole have significant efficacy in the treatment of gastroesophageal reflux in maintenance hemodialysis. (China Rural Health, 2017 (06): 20-21)
3. Wang Yumei and Song Hong conducted a study on the clinical efficacy and safety of levothyroxine sodium combined with Guipi Pills in patients with hypothyroidism and concluded that levothyroxine sodium combined with Guipi Pills has significant clinical efficacy and high safety in the treatment of patients with hypothyroidism. (General Medicine Clinical and Education, 2016, 14 (05): 532-534)
Specification
Each large honey pill weighs 9g.
Dosage
Take with warm water or ginger soup. 9g (about one bottle cap) at a time, 3 times a day.
Adverse Reactions
There have been case reports of gastrointestinal discomfort and skin rash.
Taboo
Not yet clear.
Precautions
1. Avoid foods that are difficult to digest.
2. Patients with cold and fever should not take it.
3. People with severe chronic diseases such as hypertension, heart disease, liver disease, diabetes, kidney disease, etc. should take the medicine under the guidance of a physician.
4. People with symptoms of internal heat such as thirst, yellow urine, constipation, etc. should not take it.
5. Children, pregnant women and breastfeeding women should take the medicine under the guidance of a physician.
6. If symptoms are not relieved after taking the medicine for 4 weeks, you should go to the hospital for treatment.
7. If symptoms worsen or other discomfort occurs during medication, go to the hospital for treatment.
8. People who are allergic to this product are forbidden to use it, and those with allergic constitution should use it with caution.
9. It is forbidden to use this product when its properties change.
10. Children must use this product under adult supervision.
11. Please keep this product out of reach of children.
12. If you are using other medicines, please consult your physician or pharmacist before using this product.
Drug interactions
Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Storage method
seal.
Validity
36 months
Implementation Standards
Chinese Pharmacopoeia 2010 Edition.
Identification
1. Take this product and observe it under a microscope: irregular branching masses are colorless and dissolve in chloral hydrate test solution; hyphae are colorless or light brown, with a diameter of 4-6μm (Poria cocos). The inner seed coat cells are brown-yellow, polygonal or square-shaped from the surface, and the vertical wall is thickened in a beaded manner (fried sour jujube seeds). The fibers are bundled or scattered, mostly broken, with thick walls, longitudinal cracks on the surface, and broken into broom-like or relatively flat ends (roasted Astragalus). The thin-walled cells around the fiber bundles contain calcium oxalate crystals, forming crystal fibers (roasted liquorice). The diameter of the reticulated vessels is about 90μm (Aucklandia lappa).
2. Take the test solution under [Content determination] as the test solution. Take 1g of Codonopsis pilosula as the control medicinal material and prepare the control medicinal material solution in the same way. According to the thin layer chromatography method (General Rule 0502), take 1-3μl of each of the above two solutions and spot them on the same silica gel G thin layer plate, use n-butanol-ethanol-water (7:2:1) as the developing agent, develop, take out, dry, spray with 10% sulfuric acid ethanol solution, and heat at 105℃ until the spots are clearly colored. In the chromatogram of the test sample, spots of the same color appear at the corresponding positions of the chromatogram of the control medicinal material.
3. Take 6g of honey pills of this product and grind them; or take 9g of small or large honey pills, cut them into pieces, add 50ml of methanol, ultrasonically treat for 30 minutes, filter, recover the solvent from the filtrate until dry, add 10ml of methanol to dissolve the residue, add 30ml of hydrochloric acid solution (10→100), heat and reflux for 30 minutes, cool, centrifuge, add 0.5ml of chloroform to dissolve the precipitate, and use it as the test solution. Take another reference substance of Polygala tenuifolia sapogenin, add methanol to make a solution containing 1mg per 1ml, and use it as the reference substance solution. According to the thin layer chromatography method (General Rule 0502), take 5μ of each of the above two solutions and spot them on the same silica gel G thin layer plate, use toluene-ethyl acetate-glacial acetic acid (14:8:0.5) as the developing solvent, develop, take out, dry, spray with 5% vanillin sulfuric acid solution, heat at 105℃ until the spots are clearly colored, and inspect under sunlight. In the chromatogram of the test product, a spot of the same color appears at the corresponding position in the chromatogram of the reference product.
4. Take 9g of honey pills of this product and grind them; or take 12g of small or large honey pills, cut them into pieces, add 50ml of ether, plug them tightly, soak for 4 hours, shake them from time to time, filter, evaporate the filtrate, and dissolve the residue with 1ml of methanol to prepare the test solution. Take 1g of Angelica sinensis control medicinal material and 1g of Aucklandia lappa control medicinal material, and prepare the control medicinal material solution in the same way. According to the thin layer chromatography method (General Rule 0502), take 2μl of each of the above three solutions and spot them on the same silica gel G thin layer plate, use cyclohexane-ethyl acetate (9:1) as the developing agent, develop, take out, dry, and examine under ultraviolet light (365nm). In the chromatogram of the test product, at the corresponding position of the chromatogram of the Angelica sinensis control medicinal material, a fluorescent spot of the same color appears; spray with 5% vanillin sulfuric acid solution and heat until the spot is clearly colored. In the chromatogram of the test product, at the corresponding position of the chromatogram of the Aucklandia lappa control medicinal material, a spot of the same color appears.
5. In the chromatogram of [content determination], the chromatogram of the test sample should show a chromatographic peak corresponding to the retention time of the chromatogram of the reference sample.
examine
It should comply with the relevant provisions under pills (General Rule 0108).
Content determination
Determined according to high performance liquid chromatography (General Rule 0512).
1. Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; acetonitrile-water (32:68) is used as mobile phase; evaporative light scattering detector is used for detection. The theoretical plate number calculated based on the astragaloside IV peak should be no less than 5000.
2. Preparation of reference solution: Take an appropriate amount of Astragaloside IV reference substance and accurately weigh it, add methanol to make a solution containing 0.2 mg per 1 ml.
3. Preparation of test solution: Take an appropriate amount of honey pills of this product, grind them, take 10g, and weigh accurately: or take an appropriate amount of small honey pills, cut them into pieces, take 15g, and weigh accurately; or take the large honey pills under the weight difference item, cut them into pieces, mix them, take 15g, and weigh accurately. Accurately add 100ml of methanol, weigh the weight, seal it, soak it in cold water overnight, heat it under reflux for 2 hours, let it cool, weigh it again, make up the lost weight with methanol, shake it well, filter it, accurately measure 50ml of the filtrate, recover the solvent to dryness, add 10ml of water to the residue, dissolve it with slight heat, shake it with water-saturated n-butanol for 4 times, 40ml each time, combine the n-butanol extracts, wash them thoroughly with ammonia test solution 3 times, 40ml each time, discard the washing liquid, recover the solvent with n-butanol solution to dryness, dissolve the residue with methanol, and transfer it to a 5ml volumetric flask, add methanol to the scale, shake it well, filter it, and take the filtrate to obtain it.
4. Determination method: Accurately pipette 5μl of reference solution and 20μl of test solution into liquid chromatograph respectively, and calculate with external standard two-point method logarithmic equation to get the value.
5. The content of roasted Astragalus membranaceus in this product, calculated as astragaloside IV (C 41 H 6 8 O 14 ), shall not be less than 0.10 mg per 1g of water-honey pills, not less than 57 μg per 1g of small honey pills, and not less than 0.52 mg per large honey pills.
Notes
Please read the instructions carefully and use it according to the instructions or under the guidance of a pharmacist.